Overview

Nucleic acid purification is one of the few basic methods ubiquitous among scientists using molecular biology techniques to investigate processes such as gene expression, genetic diversity, protein function and molecular interactions. The Nucleic Acid Purification Dashboard was developed from responses to a 20-question survey of 506 scientists predominantly located in North America and Europe. This Dashboard reveals key market indicators for the nucleic acid purification market as a whole as well as for the following sub-segments:

• Gel extraction
• Post-reaction cleanup (i.e. PCR, enzyme digestion)
• Plasmid DNA minipreps (1-2 ml culture)
• Plasmid DNA midipreps (5-50 ml culture)
• Plasmid DNA maxipreps (100 ml culture or more)
• Genomic DNA from cells or tissue
• Genomic DNA from whole blood
• Genomic DNA from FFPE tissue
• Total RNA from cells or tissue
• Total RNA from whole blood
• Total RNA from FFPE tissue
• mRNA
• microRNA

Percepta’s 2011 Nucleic Acid Purification Dashboard™ is a deep dive into the characteristics and dynamics of the market for nucleic acid purification products. This 2011 Dashboard provides a snapshot of the current market landscape that can be compared with data from the 2009 Nucleic Acid Dashboard, providing an ongoing story of how the market is adapting to new products, new competitors, acquisitions and new sales and marketing strategies.

Survey Methodology

In July of 2011, Percepta fielded the Nucleic Acid Purification Survey to a subset of the Percepta BioAnalytix™ Panel of life scientists. Individuals were invited by e-mail blast to click-through to a webpage at perceptabioanalytix.com where the survey was hosted. Invitations were delivered beginning on July 16, 2011 and results collected through July 29, 2011. A total of 506 scientists participated in the survey, of which 486 are actively engaged in performing nucleic acid purification and 12 plan to use nucleic acid purification methods in the next 12 months. Results based on the aggregate of collected responses are revealed in this Nucleic Acid Purification Dashboard.

Important Note: This report only includes analyses related to the research market for nucleic acid purification products and not the market for products used in diagnostic assays.

Respondent Demographics

Respondents from the academic, government and commercial market segments are well represented. 52.0% of respondents work at universities/colleges/medical schools; 8.3% are employed at hospitals/medical centers. 14.0% of respondents work for biotechnology companies; 8.5% are employed by pharmaceutical companies. Overall, 24.7% of respondents work in industrial laboratories and 72.9% of respondents work in academic laboratories.

67.6% of respondents are from North America (61.7% in the United States and 5.9% in Canada), while 31.4% reside in Europe.

Junior, mid-level and senior scientists are well represented in the data set, with the most cited job titles being Scientist/Senior Scientist (33.4% of respondents) and Professor/Principal Investigator (16.0%).

A wide variety of scientific areas of specialization is also evident, led by Molecular Biology (indicated by 28.3% of respondents as their primary area of expertise), Cell Biology (12.8%) and Biochemistry (12.5%).

Small (1-5 scientists), medium (6-20 scientists) and large (>20 scientists) laboratories are well represented. 46.3% of respondents are from laboratories where between 1 and 5 scientists perform nucleic acid purification. 42.9% of respondents work in labs where between 6 and 20 people isolate nucleic acids while the remaining 10.9% are from labs where more than 20 people perform nucleic acid isolation.

The three most common primary organisms that scientists work with when performing nucleic acid purification are: human (indicated by 38.3% of respondents), bacteria (29.6%) and mouse (16.0%)

Table of Contents

• 6 Figures and Tables
• 12 Executive Summary
• 14 Key Findings and Implications
• 19 Nucleic Acid Purification Dashboard
• 25 Nucleic Acid Purification Market Opportunity Matrix
• 27 Survey Methodology
• 29 Survey Invitation Text
• 30 Respondent Demographics
• 44 Frequency of Performance of Life Science Techniques
• 49 Frequency of Nucleic Acid Purification Product Use
• 78 Frequency of Co-Performance of Techniques and Methods
• 83 Throughput/Usage Rates and Market Growth Rates
• 90 Stated Price for Nucleic Acid Purification Products
• 94 Market Segment Sizes, Total Market Size and Total Market Growth Rate
• 96 Market Shares by Segment (Share of Mention)
• 164 Customer Satisfaction And Interest In Switching Suppliers
• 170 Product Features That Influence Purchasing Decisions
• 174 Primary and Secondary Downstream Applications
• 231 Desired Changes to Nucleic Acid Purification Products
• 242 Survey Questionnaire
• 252 Appendix

List of Figures

• 32 Figure 1: Respondents’ Place of Employment
• 34 Figure 2: Respondents’ Country/Region
• 36 Figure 3: Respondents’ Job Title
• 38 Figure 4: Respondents’ Areas of Expertise/Specialization
• 41 Figure 5: Number of Employees in Respondents’ Laboratories
• 42 Figure 6: Respondents’ Primary and Secondary Species Focus
• 46 Figure 7: Percentage of Respondents Performing Various Life Science Techniques at Least a Few Times per Year
• 52 Figure 8: Percentage of Respondents Performing Nucleic Acid Purification
• 53 Figure 8A: Change in Percentage of Respondents Performing Nucleic Acid Purification
• 54 Figure 9: Percentage of Respondents Using Various Types of Nucleic Acid Purification Products in Their Laboratories
• 56 Figure 10: Percentage of Respondents Performing Gel Extraction
• 57 Figure 11: Percentage of Respondents Performing Post-reaction Cleanup
• 58 Figure 12: Percentage of Respondents Performing Plasmid DNA Miniprep Purification
• 59 Figure 12A: Change in Percentage of Respondents Performing Plasmid DNA Miniprep Purification
• 60 Figure 13: Percentage of Respondents Performing Plasmid DNA Midiprep Purification
• 61 Figure 13A: Change in Percentage of Respondents Performing Plasmid DNA Midiprep Purification
• 62 Figure 14: Percentage of Respondents Performing Plasmid DNA Maxiprep Purification
• 63 Figure 14A: Change in Percentage of Respondents Performing Plasmid DNA Maxiprep Purification
• 64 Figure 15: Percentage of Respondents Performing Genomic DNA Purification from Cells or Tissue
• 65 Figure 15A: Change in Percentage of Respondents Performing Genomic DNA Purification from Cells or Tissue
• 66 Figure 16: Percentage of Respondents Performing Genomic DNA Purification from Whole Blood
• 67 Figure 16A: Change in Percentage of Respondents Performing Genomic DNA Purification from Whole Blood
• 68 Figure 17: Percentage of Respondents Performing Genomic DNA Purification from FFPE Tissue
• 69 Figure 18: Percentage of Respondents Performing Total RNA Purification from Cells or Tissue
• 70 Figure 18A: Change in Percentage of Respondents Performing Total RNA Purification from Cells or Tissue
• 71 Figure 19: Percentage of Respondents Performing Total RNA Purification from Whole Blood
• 72 Figure 19A: Change in Percentage of Respondents Performing Total RNA Purification from Whole Blood
• 73 Figure 20: Percentage of Respondents Performing Total RNA Purification from FFPE Tissue
• 74 Figure 21: Percentage of Respondents Performing mRNA Purification
• 75 Figure 21A: Change in Percentage of Respondents Performing mRNA Purification
• 76 Figure 22: Percentage of Respondents Performing microRNA Purification
• 77 Figure 22A: Change in Percentage of Respondents Performing microRNA Purification
• 100 Figure 23: Respondents’ Primary Supplier for Gel Extraction Products
• 104 Figure 24: Respondents’ Primary Supplier for Post-reaction Cleanup Products
• 109 Figure 25: Respondents’ Primary Supplier for Plasmid DNA Miniprep Purification Products
• 112 Figure 25A: Change in Mention of Primary Supplier for Plasmid DNA Miniprep Purification Products
• 114 Figure 26: Respondents’ Primary Supplier for Plasmid DNA Midiprep Purification Products
• 117 Figure 26A: Change in Mention of Primary Supplier for Plasmid DNA Midiprep Purification Products
• 119 Figure 27: Respondents’ Primary Supplier for Plasmid DNA Maxiprep Purification Products
• 122 Figure 27A: Change in Mention of Primary Supplier for Plasmid DNA Maxiprep Purification Products
• 125 Figure 28: Respondents’ Primary Supplier for Purifying Genomic DNA from Cells or Tissue
• 128 Figure 28A: Change in Mention of Primary Supplier for Purifying Genomic DNA from Cells or Tissue
• 130 Figure 29: Respondents’ Primary Supplier for Purifying Genomic DNA from Whole Blood
• 133 Figure 29A: Change in Mention of Primary Supplier for Purifying Genomic DNA from Whole Blood
• 135 Figure 30: Respondents’ Primary Supplier for Purifying Genomic DNA from FFPE Tissue
• 140 Figure 31: Respondents’ Primary Supplier for Purifying Total RNA from Cells or Tissue
• 143 Figure 31A: Change in Mention of Primary Supplier for Purifying Total RNA from Cells or Tissue
• 145 Figure 32: Respondents’ Primary Supplier for Purifying Total RNA from Whole Blood
• 148 Figure 32A: Change in Mention of Primary Supplier for Purifying Total RNA from Whole Blood
• 150 Figure 33: Respondents’ Primary Supplier for Purifying Total RNA from FFPE Tissue
• 154 Figure 34: Respondents’ Primary Supplier for Purifying mRNA
• 157 Figure 34A: Change in Mention of Primary Supplier for Purifying mRNA
• 159 Figure 35: Respondents’ Primary Supplier for Purifying microRNA
• 162 Figure 35A: Respondents’ Primary Supplier for Purifying microRNA
• 169 Figure 36: Percentage of Respondents That Have Switched Suppliers in the Last Six Months
• 172 Figure 37: Most Important Features of Products for Nucleic Acid Purification
• 176 Figure 38: Respondents’ Primary Application for Purified Gel Extraction Nucleic Acids
• 178 Figure 39: Respondents’ Primary & Secondary Applications for Purified Gel Extraction Nucleic Acids
• 180 Figure 40: Respondents’ Primary Application for Purified Post-reaction Cleanup Nucleic Acids
• 182 Figure 41: Respondents’ Primary & Secondary Applications for Purified Post-reaction Cleanup Nucleic Acids
• 186 Figure 42: Respondents’ Primary Application for Purified Plasmid Miniprep DNA
• 188 Figure 43: Respondents’ Primary & Secondary Applications for Purified Plasmid Miniprep DNA
• 190 Figure 44: Respondents’ Primary Application for Purified Plasmid Midiprep DNA
• 192 Figure 45: Respondents’ Primary & Secondary Applications for Purified Plasmid Midiprep DNA
• 194 Figure 46: Respondents’ Primary Application for Purified Plasmid Maxiprep DNA
• 196 Figure 47: Respondents’ Primary & Secondary Applications for Purified Plasmid Maxiprep DNA
• 200 Figure 48: Respondents’ Primary Application for Genomic DNA Purified from Cells or Tissue
• 202 Figure 49: Respondents’ Primary & Secondary Applications for Genomic DNA Purified from Cells or Tissue
• 204 Figure 50: Respondents’ Primary Application for Genomic DNA Purified from Whole Blood
• 206 Figure 51: Respondents’ Primary & Secondary Applications for Genomic DNA Purified from Whole Blood
• 208 Figure 52: Respondents’ Primary Application for Genomic DNA Purified from FFPE Tissue
• 210 Figure 53: Respondents’ Primary & Secondary Applications for Genomic DNA Purified from FFPE Tissue
• 214 Figure 54: Respondents’ Primary Application for Total RNA Purified from Cells or Tissue
• 216 Figure 55: Respondents’ Primary & Secondary Applications for Total RNA Purified from Cells or Tissue
• 218 Figure 56: Respondents’ Primary Application for Total RNA Purified from Whole Blood
• 220 Figure 57: Respondents’ Primary & Secondary Applications for Total RNA Purified from Whole Blood
• 222 Figure 58: Respondents’ Primary Application for Total RNA Purified from FFPE Tissue
• 223 Figure 59: Respondents’ Primary & Secondary Applications for Total RNA Purified from FFPE Tissue
• 225 Figure 60: Respondents’ Primary Application for Purified mRNA
• 226 Figure 61: Respondents’ Primary & Secondary Applications for Purified mRNA
• 228 Figure 62: Respondents’ Primary Application for Purified microRNA
• 229 Figure 63: Respondents’ Primary & Secondary Applications for Purified microRNA
• 254 Figure 64: Non-current Users of Nucleic Acid Purification Products – Future Plans

List of Tables

• 39 Table 1: Respondents’ Areas of Expertise/Specialization (Values for Figure 4)
• 47 Table 2: Frequency of Performance of Various Life Science Techniques
• 48 Table 3: Frequency of Co-Performance of Various Life Science Techniques
• 55 Table 4: Frequency of Use for Various Nucleic Acid Purification Products
• 80 Table 5: Frequency of Co-Performance of Life Science Techniques with Various Nucleic Acid Purification Methods
• 81 Table 6: Frequency of Co-Performance of Nucleic Acid Purification Methods with Various Life Science Techniques
• 82 Table 7: Co-Performance of Various Nucleic Acid Purification Methods
• 85 Table 8: Median and Average Monthly Throughput for Nucleic Acid Purification Methods
• 86 Table 8A: Change in Median Monthly Throughput for Nucleic Acid Purification Methods
• 87 Table 9: Percentage of Respondents Performing Various Numbers of Purification Reactions Per Month
• 82 Table 10: Projected Growth Rates for Various Nucleic Acid Purification Methods
• 92 Table 11: Median and Average Price Per Prep for Nucleic Acid Purification Products
• 93 Table 11A: Change in Median and Average Price Per Prep for Nucleic Acid Purification Products
• 95 Table 12: Estimated 2012 Global Market Size for Nucleic Acid Purification Products by Category
• 98 Table 13: Respondents’ Primary Supplier for Nucleic Acid Purification Products
• 102 Table 14: Respondents’ Primary Supplier for Gel Extraction Products by Market Segment
• 106 Table 15: Respondents’ Primary Supplier for Post-reaction Cleanup Products by Market Segment
• 107 Table 16: Market Share Leaders for Gel Extraction and Post-reaction Cleanup Products
• 111 Table 17: Respondents’ Primary Supplier for Plasmid DNA Miniprep Purification Products by Market Segment
• 116 Table 18: Respondents’ Primary Supplier for Plasmid DNA Midiprep Purification Products by Market Segment
• 121 Table 19: Respondents’ Primary Supplier for Plasmid DNA Maxiprep Purification Products by Market Segment
• 123 Table 20: Market Share Leaders for Plasmid DNA Purification Products
• 127 Table 21: Respondents’ Primary Supplier for Purifying Genomic DNA from Cells or Tissue by Market Segment
• 132 Table 22: Respondents’ Primary Supplier for Purifying Genomic DNA from Whole Blood by Market Segment
• 137 Table 23: Respondents’ Primary Supplier for Purifying Genomic DNA from FFPE Tissue Products by Market Segment
• 138 Table 24: Market Share Leaders for Genomic DNA Purification Products
• 142 Table 25: Respondents’ Primary Supplier for Purifying Total RNA from Cells or Tissue by Market Segment
• 147 Table 26: Respondents’ Primary Supplier for Purifying Total RNA from Whole Blood by Market Segment
• 152 Table 27: Respondents’ Primary Supplier for Purifying Total RNA from FFPE Tissue by Market Segment
• 156 Table 28: Respondents’ Primary Supplier for Purifying mRNA by Market Segment
• 161 Table 29: Respondents’ Primary Supplier for Purifying microRNA by Market Segment
• 163 Table 30: Market Share Leaders for RNA Purification Products
• 166 Table 31: Percentage of Respondents Satisfied with Various Nucleic Acid Purification Product Categories and Reasons for Dissatisfaction
• 167 Table 32: Percentage of Respondents Satisfied with Nucleic Acid Purification Product Categories – Comparison to 2009 Nucleic Acid Purification Dashboard
• 173 Table 33: Most Important Features of Products for Nucleic Acid Purification – Comparison to 2009 Nucleic Acid Purification Dashboard

 

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